Ms Giuffre, 38, accuses the Duke of York of allowing billionaire paedophile Jeffrey Epstein to have sex with her three times as a teenager.
He accuses Ms Giuffre of pursuing ‘another payday at his expense' in a decade-long quest to benefit from her claims against the disgraced banker and his colleagues.
According to the duke, the settlement agreement between Ms Giuffre and Epstein safeguards him from any legal action.
If the ruling goes against Andrew, he may face a jury trial as early as September. Previously, opposing lawyers would interrogate the duke and Ms Giuffre under oath.
Andrew may seek an out-of-court settlement to avoid having to testify — and the chance of new charges appearing during the trial.
A trial might also overshadow the Queen's Platinum Jubilee celebrations in June, further damaging the Royal Family's reputation.
In 2009, Ms Giuffre received £370,000 to settle her claim against the billionaire, according to their 12-page agreement.
According to the Independent, she received £7 million ($10 million) in exchange for her quiet on additional charges.
‘He has been very clear that he wants to clean his name,' a person close to Prince Andrew told The Times.
Ms Giuffre is also believed to be determined to prosecute the duke and demonstrate that even those ‘with power and luxury' will face justice.
Meanwhile, Prince Andrew's lawyers can argue that Ms Giuffre cannot sue since she is not a US resident.
The judge has already rejected a request to stop the case and the exchange of evidence.
But Andrew's lawyers haven't presented the defence that the lawsuit can't proceed since Ms Giuffre lives in Australia, not Colorado, as her team claims.
‘They believe they have a genuine argument to get this thrown out,' said another person close to Andrew's legal team.
‘If they can show that there is precedent not to bring a case if both parties are not US residents, then it should be stopped immediately.'
The judge's ruling said nothing about the prince's assertion that Ms Giuffre couldn't sue since she lived in Australia.
He gave her till January 14 to verify her residency.
In 2019, Epstein was discovered dead in his cell while awaiting a sex trafficking trial in New York. His suicide was ruled.
Between 1994 and 2004, his ex-girlfriend Ghislaine Maxwell, 60, was convicted in the US of helping him lure vulnerable teenagers to Epstein's residences for sexual assault.
The prosecution called her ‘dangerous' and she faced life in prison.
Ms Giuffre's civil lawsuit against the duke has been reopened due to her acquaintance with Andrew.